Alcohol Metabolism : Reactions & Biochemical Changes | Clinical Question | Biochemistry | Dr. Rajesh
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ЁЯОп Alcohol Metabolism : Lipid Metabolism тАв Biochemistry тАв MBBS тАв Dr. Rajesh Tanwar
Alcohol Metabolism biochemistry ka important topic hai jo mainly liver me hota hai. Jab ethanol body me enter karta hai, to sabse pehle enzyme Alcohol Dehydrogenase (ADH) ethanol ko acetaldehyde me convert karta hai. Ye reaction cytosol me hoti hai aur is process me NADтБ║ тЖТ NADH ban jata hai.
Uske baad highly toxic acetaldehyde ko mitochondria me enzyme Aldehyde Dehydrogenase (ALDH) convert karke acetate bana deta hai. Acetate further acetyl-CoA me convert ho kar TCA cycle ya fatty acid synthesis me use ho sakta hai.
Alcohol metabolism ke dauran excess NADH formation hoti hai, jis se metabolic imbalance develop ho sakta hai jaise fatty liver, lactic acidosis, aur hypoglycemia. Chronic alcohol consumption se liver damage aur metabolic disorders ka risk bhi badh jata hai.
ЁЯСЙ Short me: Ethanol тЖТ Acetaldehyde тЖТ Acetate, mainly liver me enzymes ADH aur ALDH ke through metabolize hota hai.
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